PACC 2024

PolyAnalgesic Consensus Conference®

PACC 2024

PolyAnalgesic

Consensus Conference®

Introduction

The Pain Website was first released in response to providers’ request for a more readily accessible way to review the 2016 PolyAnalgesic Consensus Conference (PACC) panel recommendations. Our goal was to make it easy for you to reference and integrate the recommendations at your practice.

2017 was the first iteration and involved not only the algorithms and text descriptions, but also verbal reading of the text and algorithm by Drs. Tim Deer and Gladstone C. McDowell II.

As the PACC publications are a living document, the information from the 2016 publication is still relevant with additional guidance, based on the new evidence identified.

For the 2024 second edition, the PACC panel recommendations, charts and references are presented in an easy-to visualize format. This edition includes a new color scheme and updated graphics.

The authors and International Neuromodulation Society would like to thank TerSera Therapeutics for the unrestricted grant used to develop, and maintain, this recent iteration of the PACC app. Gladstone C McDowell II MD

Source(s) of financial support:

The Polyanalgesic Consensus Conference publications were supported by the International Neuromodulation Society and no authors were paid for their contributions.

The Polyanalgesic Consensus Conference Mobile Application (PACC App) development was supported by a grant from Tersera Therapeutics. No authors were paid for their contributions to the application.

Introduction

The Pain Website was first released in response to providers’ request for a more readily accessible way tao review the 2016 PolyAnalgesic Consensus Conference (PACC) panel recommendations. Our goal was to make it easy for you to reference and integrate the recommendations at your practice.

This was the first iteration and involved not only the algorithms and text descriptions, but also verbal reading of the text and algorithm by Drs. Tim Deer and Gladstone C. McDowell II.

As the PACC publications are a living document, the information from the 2016 publication is still relevant with additional guidance, based on the new evidence identified.

For the second edition, the PACC panel recommendations, charts and references are presented in an easy-to visualize format. This edition includes a new color scheme and updated graphics.

The authors and International Neuromodulation Society would like to thank TerSera Therapeutics for the unrestricted grant used to develop, and maintain, this recent iteration of the PACC app.- Gladstone C McDowell II MD

Source(s) of financial support:

The Polyanalgesic Consensus Conference publications were supported by the International Neuromodulation Society and no authors were paid for their contributions.

The Polyanalgesic Consensus Conference Mobile Application (PACC App) development was supported by a grant from Tersera Therapeutics. No authors were paid for their contributions to the application.

Introduction

The Pain Website was first released in response to providers’ request for a more readily accessible way to review the 2016 PolyAnalgesic Consensus Conference (PACC) panel recommendations. Our goal was to make it easy for you to reference and integrate the recommendations at your practice.

2017 was the first iteration and involved not only the algorithms and text descriptions, but also verbal reading of the text and algorithm by Drs. Tim Deer and Gladstone C. McDowell II.

As the PACC publications are a living document, the information from the 2016 publication is still relevant with additional guidance, based on the new evidence identified.

For the 2024 second edition, the PACC panel recommendations, charts and references are presented in an easy-to visualize format. This edition includes a new color scheme and updated graphics.

The authors and International Neuromodulation Society would like to thank TerSera Therapeutics for the unrestricted grant used to develop, and maintain, this recent iteration of the PACC app.- Gladstone C McDowell II MD

Source(s) of financial support:

The Polyanalgesic Consensus Conference publications were supported by the International Neuromodulation Society and no authors were paid for their contributions.

The Polyanalgesic Consensus Conference Mobile Application (PACC App) development was supported by a grant from Tersera Therapeutics. No authors were paid for their contributions to the application.

History

In 2000 a PolyAnalgesic Consensus Conference was organized to review and evaluate the existing literature to enable development of guidelines for intrathecal drug selection. This was the first offering of its kind supported by experienced practitioners from academic and private practice. The algorithm for drug selection was based on the best available evidence and served as a basis for more effective management of intrathecal drug delivery devices.

In 2003, the second conference was convened with the following goals:

To review the literature of interest on intraspinal drug infusion since 1999

To revise the 2000 drug selection algorithm

To develop guidelines for optimizing drug dosage and concentrations

To create a process for documenting minimum evidence supporting the use of a drug for intraspinal infusion

To clarify issues pertaining to compounding of drugs

History

In 2000 a PolyAnalgesic Consensus Conference was organized to review and evaluate the existing literature to enable development of guidelines for intrathecal drug selection. This was a first offering of its kind supported by experienced practitioners from academic and private practice. The algorithm for drug selection was based on the best available evidence and served as a basis for more effective management of intrathecal drug delivery devices.

In 2003, the second conference was convened with the following goals:

To review the literature on interest by the drug infusion since 1999

To revise the 2000 drug selection algorithm

To develop guidelines for optimizing, drug dosage and concentrations

To create a process for documenting minimum evidence, supporting the use of a drug for interest, spinal infusion

To clarify, issues pertaining to compounding of drugs

History

In 2000 a PolyAnalgesic Consensus Conference was organized to review and evaluate the existing literature to enable development of guidelines for intrathecal drug selection. This was a first offering of its kind supported by experienced practitioners from academic and private practice. The algorithm for drug selection was based on the best available evidence and served as a basis for more effective management of intrathecal drug delivery devices.

In 2003, the second conference was convened with the following goals:

To review the literature of interest on intraspinal drug infusion since 1999

To revise the 2000 drug selection algorithm

To develop guidelines for optimizing, drug dosage and concentrations

To create a process for documenting minimum evidence supporting the use of a drug for intraspinal infusion

To clarify, issues pertaining to compounding of drugs

Faculty

Gladstone C. McDowell II, M.D.

President, Targeted Care Solutions
Founder and Former Medical Director Integrated Pain Solutions, Columbus, Ohio

Timothy R. Deer M.D. DABPM, FIPP

President and CEO, The Spine and Nerve Center of The Virginias
Clinical Professor of Anesthesiology and Pain Medicine West Virginia University School of Medicine

Faculty

Gladstone C McDowell II, M.D.

President, Targeted Care Solutions
Founder and Former Medical Director Integrated Pain Solutions, Columbus, Ohio

Timothy R. Deer M.D. DABPM, FIPP

President and CEO, The Spine and Nerve Center of The Virginias
Clinical Professor of Anesthesiology and Pain Medicine West Virginia University School of Medicine

Faculty

Gladstone C. McDowell II, M.D.

President, Targeted Care Solutions
Founder and Former Medical Director Integrated Pain Solutions, Columbus, Ohio

Timothy R. Deer M.D. DABPM, FIPP

President and CEO, The Spine and Nerve Center of The Virginias
Clinical Professor of Anesthesiology and Pain Medicine West Virginia University School of Medicine

Guidelines Development Process

The International Neuromodulation Society® once again, convened an international multispecialty group of physicians and scientists based on expertise to establish evidence-based guidelines on intrathecal drug delivery for treatment of chronic intractable pain.

This 2024 publication of the PACC project continues our mission of providing evidence-based guidance for important safety and efficacy issues surrounding intrathecal drug delivery, and it’s impact on the practice of neuromodulation.

The choice of authors was based on their clinical expertise, familiarity with peer-reviewed literature, research productivity, and contributions to the neuromodulation literature. Section leaders supervised literature searches of Medline, BioMed Central, Current Contents Connect, Embase, International Pharmaceutical Abstracts, Web of Science, Google Scholar, and PubMed, from 2017, (when PACC last published guidelines) to the present.

The current update is based on the various recently published articles and we have collected the references and established links for the different sections.

2024 PACC update has also been reviewed and vetted by International Neuromodulation Society Board members for it’s content and accuracy.

The International Neuromodulation Society once again, convened in international multispecialty group of physicians and scientist based on expertise to establish evidence-based guidelines on intrathecal drug delivery for treatment of chronic intractable pain.

This 2024 publication of the PACC project continues our mission of providing evidence-based guidance for important safety and efficacy issues surrounding intrathecal drug delivery, and it’s impact on the practice of neuromodulation.

The choice of authors was based on their clinical expertise, familiarity with a peer-reviewed, literature, research productivity, and contributions to the neuromodulation literature. Section leaders supervised literature searches of Medline, BioMed Central, Current Contents Connect, Embase, International Pharmaceutical Abstracts, Web of Science, Google Scholar, and PubMed, from 2017, (when PACC last published guidelines) to the present.

The current update is based on the various recently published articles and we have collected the references and established hyperlinks for the different sections.

2024 PACC update has also been reviewed and vetted by International Neuromodulation Society Board members for it’s content and accuracy.

The International Neuromodulation Society once again, convened in international multispecialty group of physicians and scientist based on expertise to establish evidence-based guidelines on intrathecal drug delivery for treatment of chronic intractable pain.

This 2024 publication of the PACC project continues our mission of providing evidence-based guidance for important safety and efficacy issues surrounding intrathecal drug delivery, and it’s impact on the practice of neuromodulation.

The choice of authors was based on their clinical expertise, familiarity with a peer-reviewed, literature, research productivity, and contributions to the neuromodulation literature. Section leaders supervised literature searches of Medline, BioMed Central, Current Contents Connect, Embase, International Pharmaceutical Abstracts, Web of Science, Google Scholar, and PubMed, from 2017, (when PACC last published guidelines) to the present.

The current update is based on the various recently published articles and we have collected the references and established hyperlinks for the different sections.

2024 PACC update has also been reviewed and vetted by International Neuromodulation Society Board members for it’s content and accuracy.

More effective management of intrathecal drug delivery.

More effective management of intrathecal drug delivery devices.