The refilling procedure should follow a strict protocol, including ensuring that dosage changes are properly calculated and documented³⁰. A secondary review by another healthcare provider is recommended to minimize errors.

Patients should be positioned lying down rather than sitting for the refilling procedure. Echography may be used to identify the pump location, particularly in patients with a thick abdominal wall¹⁶⁵. Monitoring the volume of old medication removed is crucial; discrepancies of more than 1 mL could indicate catheter obstruction or other complications.

A brief monitoring period (e.g., 30 minutes) after refills is advised, and clear communication about the next appointment and any significant medication changes should be provided to the patient and their caregivers.